The target article does not address the neural mediation of complex social behavior. I review evidence that such mediation may be compatible with proposed Bayesian information-processing principles. Notably, however, such mediation occurs subcortically as well as cortically, concerns reward uncertainty and information uncertainty, and impacts culture via group-level payoff structures that define individualism and collectivism.

DNA double‐strand breaks (DSBs) are extremely hazardous lesions for all DNA‐bearing organisms and the mechanisms of DSB repair are highly conserved. In the eukaryotic mitotic cell cycle, DSBs are often present following DNA replication while, in meiosis, hundreds of DSBs are generated as a prelude to the reshuffling of the maternally and paternally derived genomes. In both cases, the DSBs are repaired by a process called homologous recombinational repair (HRR), which utilises an intact DNA molecule as the repair template. (...) Mitotic and meiotic HRR are managed by ‘checkpoints’ that inhibit cell division until DSB repair is complete. Here we attempt to summarise the substantial recent progress in understanding the checkpoint management of HRR in mitosis (focussing mainly on mammals) and then go on to use this information as a framework for understanding the presumed checkpoint management of HRR in mammalian meiosis. BioEssays 29:974–986, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In many countries publications in Web of Knowledge journals are dominant in the evaluation of educational research. For various purposes comparisons are made between the output of philosophers of education in these journals and the publications of their colleagues in educational research generally, sometimes also including psychologists and/or social scientists. Taking its starting-point from Hayden’s article in this journal , this paper discusses the situation of educational research in three countries: The Netherlands, South Africa and Norway. In this paper an (...) alternative for comparing research output is offered by invoking comparisons with colleagues at the international level from within the same sub-discipline. It is argued that if one would do so a different picture would emerge, even if one were to limit oneself to particular kinds of publications. The case is then made that if comparisons are regarded as a necessary part of the evaluation of an individual scholar , it would be more fair to use a proxy system which is sub-discipline specific, or minimally contains some kind of correction factor in relation to the over-all quality assessment device. Debates about the relevance or irrelevance of philosophy of education in the context of educational sciences are now obscured, even poisoned by focusing almost exclusively on a particular kind of publication output. As the ‘reward’ system that is developed accordingly is possibly the most important driver of educational research, it puts the sub-discipline unduly under pressure to the extent that it possibly cannot survive. (shrink)

The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing the (...) 5'-flanking region of the human APOE gene . Sequence analysis of this region suggests the presence of two potential NF-B elements. To demonstrate promoter activity, the region was cloned upstream of a promoterless luciferase gene. This segment was able to drive expression of luciferase in transient transfections of human fetal glial cells. Promoter activity was stimulated twofold by A treatment. Pretreatment with double-stranded DNA decoy oligonucleotides against NF-B reduced A stimulation. Deletion and mutagenetic analyses demonstrated that the distal NF-B element was functional and showed a strong DNA-protein complex band in gel shift analysis, similar to that from control NF-B consensus element. An anti-inflammatory and anti-NF-B drug, sodium salicylate, significantly blocked A-induced APOE promoter function. Our data provide evidence that upregulation of APOE by A in astroglial cells is mediated by an NF-B-element present in the 5'-flanking region of the APOE gene. (shrink)

ABSTRACT:Stanley Cavell’s moral perfectionism places the task of cultivating richer self-understanding and self-expression at the center of corporate life. We show how his approach reframes business as an opportunity for moral soul-craft, achieved through the articulation of increasingly reflective inner life in organizational culture. Instead of norming constraints on business activity, perfectionism opens new possibilities for conducting commercial exchange as a form of conversation, leading to personal growth. This approach guides executives in designing businesses that foster genius and channel creativity, (...) while giving all stakeholders a meaningful voice within a culture of trust. We first give an account of Cavellian perfectionism. Then, we explain how this underrepresented strand of moral reflection challenges and enriches, but does not supplant, prevailing ethical theories—including other versions of perfectionism. We then demonstrate the salience of Cavellian perfectionism to business ethics through examples from marketing, human resources, and executive organizational design and development. (shrink)

By blending multiple strands of thought into one ideology, Chinese Syncretists of the pre-imperial period created an essential guide to contemporary ideas about self, society, and government. Merging traditions such as Ruism, Mohism, Daoism, Legalism, and Yin-Yang naturalism into their work, Syncretists created an integrated intellectual approach that contrasts with other, more specific philosophies. Presenting the first full English translation of the earliest example of a Syncretist text, this volume introduces Western scholars to both the brilliance of the syncretic method (...) and a critical work of Chinese leadership. Written by Shi Jiao, China's first syncretic thinker, during the Warring States Period of 481 to 221 BCE, _Shizi_ is similar to Machiavelli's _The Prince_ in that it dispenses wisdom to would-be rulers. It stresses the need for leaders to be detached and objective. It further encourages self-cultivation and effective government, recommending that rulers maintain self-discipline, hire reliable people, delegate power transparently, and promote others in an orderly fashion. The people, it is argued, will emulate their leader's wisdom and virtue, and a just and peaceful state will result. Paul Fischer provides an extensive introduction and a chapter-by-chapter summary and analysis of the text--outlining the importance of syncretism in Chinese culture--and explores the text's particular features, authorship, transmission, loss, and reconstruction over time. The _Shizi_ set the stage for a long history of syncretic endeavor in China, and its study provides insight into the vital traditions of early Chinese philosophy. It is also a template for interpreting other well-known works, such as the Confucian _Analects_, the Daoist _Laozi_, the Mohist _Mozi_, and the Legalist _Shang jun shu_. (shrink)

This article is concerned with a central strand of Strawson's well-known and highly influential essay “Freedom and Resentment” Strawson's principal objectives in this work is to refute or discredit the views of the "Pessimist." The Pessimist, as Strawson understands him/ her, claims that the truth of the thesis of determinism would render the attitudes and practices associated with moral responsibility incoherent and unjustified. Given this, the Pessimist claims that if determinism is true, then we must abandon or suspend these (...) attitudes and practices altogether. Against the Pessimist Strawson argues that no reasoning of any sort could lead us to abandon or suspend our "reactive attitudes." That is to say, according to Strawson responsibility is a "given" of human life and society-something which we are inescapably committed to. In this article I argue that Strawson's reply to the Pessimist is seriously flawed. More specifically, I argue that Strawson fails to distinguish two very different forms or modes of naturalism and that he is constrained by the nature of his own objectives (i.e., the refutation of Pessimism) to embrace the stronger and far less plausible form of naturalism. On this basis I conclude that while there is something to be said for Strawson's general approach to these matters, we nevertheless cannot naturalize responsibility along the specific lines that he suggests. (shrink)

Recent work in the history of philosophy of science details the Kantianism of philosophers often thought opposed to one another, e.g., Hans Reichenbach, C.I. Lewis, Rudolf Carnap, and Thomas Kuhn. Historians of philosophy of science in the last two decades have been particularly interested in the Kantianism of Reichenbach, Carnap, and Kuhn, and more recently, of Lewis. While recent historical work focuses on recovering the threatened-to-be-forgotten Kantian themes of early twentieth-century philosophy of science, we should not elide the differences between (...) the Kantian strands running throughout this work. In this paper, I disentangle a few of these strands in the work of Reichenbach and Lewis focusing especially on their theories of relativized, constitutive a priori principles in empirical knowledge. In particular, I highlight three related differences between Reichenbach and Lewis concerning their motivations in analyzing scientific knowledge and scientific practice, their differing conceptions of constitutivity, and their relativization of constitutive a priori principles. In light of these differences, I argue Lewis’s Kantianism is more similar to Kuhn’s Kantianism than Reichenbach’s, and so might be of more contemporary relevance to social and practice-based approaches to the philosophy of science. (shrink)

This article motivates a shift in certain strands of the debate over legitimate roles for nonepistemic values in scientific practice from investigating what is involved in taking cognitive attitudes like acceptance toward an empirical hypothesis to looking at a social understanding of assertion, the act of communicating that hypothesis. I argue that speech act theory’s account of assertion as a type of doing makes salient legitimate roles nonepistemic values can play in scientific practice. The article also shows how speech act (...) theory might provide a framework for fruitfully extending aspects of the social and pragmatic turns in the philosophy of science. (shrink)

By blending multiple strands of thought into one ideology, Chinese Syncretists of the pre-imperial period created an essential guide to contemporary ideas about self, society, and government. Merging traditions such as Ruism, Mohism, Daoism, Legalism, and Yin-Yang naturalism into their work, Syncretists created an integrated intellectual approach that contrasts with other, more specific philosophies. Presenting the first full English translation of the earliest example of a Syncretist text, this volume introduces Western scholars to both the brilliance of the syncretic method (...) and a critical work of Chinese leadership. -/- Written by Shi Jiao, China’s first syncretic thinker, during the Warring States Period of 481 to 221 BCE, Shizi is similar to Machiavelli’s The Prince in that it dispenses wisdom to would-be rulers. It stresses the need for leaders to be detached and objective. It further encourages self-cultivation and effective government, recommending that rulers maintain self-discipline, hire reliable people, delegate power transparently, and promote others in an orderly fashion. The people, it is argued, will emulate their leader’s wisdom and virtue, and a just and peaceful state will result. Paul Fischer provides an extensive introduction and a chapter-by-chapter summary and analysis of the text—outlining the importance of syncretism in Chinese culture—and explores the text’s particular features, authorship, transmission, loss, and reconstruction over time. The Shizi set the stage for a long history of syncretic endeavor in China, and its study provides insight into the vital traditions of early Chinese philosophy. It is also a template for interpreting other well-known works, such as the Confucian Analects, the Daoist Laozi, the Mohist Mozi, and the Legalist Shang jun shu. (shrink)

In her influential and challenging paper “Skepticism about Practical Reason” Christine Korsgaard sets out to refute an important strand of Humean scepticism as it concerns a Kantian understanding of practical reason.1 Korsgaard distinguishes two components of scepticism about practical reason. The first, which she refers to as content scepticism, argues that reason cannot of itself provide any “substantive guidance to choice and action” (SPR, 311). In its classical formulation, as stated by Hume, it is argued that reason cannot determine (...) our ends. Our ends are determined by our desires and reason is limited to the role of identifying the relevant means to these ends. The second component, which Korsgaard calls motivational scepticism, suggests doubt about the scope of reason as a motive. The claim here, as Korsgaard interprets Hume’s view on this matter, is that “all reasoning that has motivational influence must start from a passion, that being the only possible source of motivation” (SPR, 314).2 Korsgaard’s fundamental objective in “Skepticism about Practical Reason” is to show that motivational scepticism must always be based on content scepticism. In other words, according to Korsgaard, motivational scepticism has no independent force. In this paper I argue that Korsgaard’s attempt to discredit motivational scepticism is unsuccessful. (shrink)

This article illustrates Sheila Dow's notion of ‘structured pluralism’ drawing on a recent empirical body of literature in which multiple research, or ‘Q-Squared’, approaches to causal analysis of poverty analysis have been used in the Global South. It maintains that understanding linguistic differences between schools of thought is quite integral to methodologically-aware critique and to improved methodological practice. The various strands in the Q2 literature together provide a case for methodological pluralism based on claims that knowledge is partial, empirical adjudication (...) is imperfect, the world is complex and combining multiple research approaches adds value. The goals of understanding and explanation are best served if research questions dictate choice of methodological approach rather than the other way around. (shrink)

In this paper, I explore Wittgenstein’s inheritance of one specific strand of Kant’s criticism, in the Critique of Pure Reason, of reason’s inherent pretensions to totality. This exploration reveals new critical possibilities in Wittgenstein’s own philosophical method, challenging existing interpretations of Wittgenstein’s political thought as “conservative” and exhibiting the closeness of its connection to another inheritor of Kant’s critique of totality, the Frankfurt school’s criticism of “identity thinking” and the reification of reason to which it leads. Additionally, it shows (...) how Wittgenstein’s linguistic philosophy offers to challenge and undermine, in a historically novel way, the metaphysical assumptions underlying some of our most characteristic and ubiquitous social practices. (shrink)

John Kinsella’s three-volume Graphology Poems: 1995–2015 constitutes a major and shifting set of poetic statements. Partly a discontinuous poetic chronicle of life in Western Australia’s Avon Valley, they are also an investigation of ways in which an activist poetry may inscribe aspects of being, self and experience while protesting against environmental challenges and degradation. As these poems sprawl in many directions and express overlapping preoccupations, and as they emphasise the unsettled and unstable while affirming what has a continuing importance, so (...) they constitute a series of ethical positions connected to living sustainably and responsibly. They also explore the porous nature of a poetic activism that steps out into the quotidian world while simultaneously refashioning the poetic, challenging and even subverting the language of the contemporary lyric and the contemporary pastoral. The Graphology poems prize incompleteness and the fragmentary, open out to reveal absences and imply other texts, value multiple meanings and represent many of the most important strands of Kinsella’s work. (shrink)

ABSTRACT This essay challenges the view that John Rawls's recently published undergraduate thesis A Brief Inquiry into the Meaning of Sin and Faith provides little help in understanding his mature work. Two crucial strands of Rawls's Theory of Justice are its critique of teleology and its claims about our moral nature and its expression. These strands are brought together in a set of arguments late in Theory which are important but have attracted little sustained attention. I argue that the target (...) of Rawls's undergraduate thesis is a form of Christianity which rests on assumptions Rawls later came to think were fundamental to teleological views, and that the thesis defends an alternative form of religiosity that anticipates what Rawls says in Theory about the expression of our nature. Those sections of Theory also provide resources Rawls could have used to respond to a number of prominent and recurrent criticisms of his account of moral motivation. Seeing the continuities between Brief Inquiry and Theory of Justice shows how long Rawls wrestled with problems he took up in the neglected sections of Theory and thereby shows their importance to Rawls's thought. (shrink)

Axiomatic and problematic approaches to ontology are discussed, at first in relation to the work of Badiou and Deleuze in mathematics. This discussion is then broadened focussing on problematics in Deleuze and Guattari’s critiques of capitalism and psychoanalysis which results in an analysis of the implications of this discussion for education. From this, education as being already there, which is an assumption in some strands of philosophy of education, following Deleuze’s critique of axiomatic presentations of ontological identities, is described as (...) a repressive, stabilizing operation, which produces objectives which are characterized as peculiar things. By contrast, those aspects of practice, knowledge, behaviours and populations which cannot be accommodated and resolved by axiomatic formulae and fall from axiomatic systems are characterized as queer things that constitute counter cultures. (shrink)

I argue that we can find in Marx two objections to exploitation: an entitlement objection according to which it is wrongful because of the unjust distribution of benefits and burdens it generates; and an expressivist objection according to which it is objectionable because of the kind of social relation it is. The expressivist objection is predicated on a communitarian strand in Marx's thought, whereas the entitlement objection is grounded in a more liberal account of the wrongfulness of capitalist exploitation. (...) I conclude by connecting my analysis to the current debate between proponents and critics of market socialism. While market socialism could be a vehicle for realizing the values associated with the entitlement objection, this is not true for the expressivist objection. Furthermore, because the entitlement objection does not depend on a thick conception of the human good, it is in accord with the liberal ideal of political neutrality whereas the expressivist objection is not. (shrink)

Robert Nozick has attempted to demonstrate that a state can emerge from anarchy which will be legitimate, in that it acquires power in morally permissible (i.e., non rights violating) ways. Its monopoly on force and apparent redistribution of holdings are, according to Nozick, justified by the steps required to prevent risky behavior by the dominant agency. These steps, I argue, contravene Nozick's own entitlement principles and so, his dominant agency is not warranted in taking them. This leaves Nozick "stranded" within (...) his own state of nature, the dominant agency unable to legitimately transform itself into a night watchman state. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Murder in the Garden? The Envy of the Gods in Genesis 2 and 3 Paul DuffJoseph Hallman George Washington University University of St. Thomas According to Walter Brueggemann, "No text in Genesis (or likely in the entire Bible) has been more used, interpreted and misunderstood" than the story of Adam and Eve in the garden. "This applies to careless, popular theology as well as to the doctrine of (...) the church"(41). Augustine attempted to explain the first few chapters of Genesis on no fewer than five different occasions throughout his career. Based on his reading ofPaul, Augustine and Western Christianity after him believed that the entire human race inherited the disobedience ofAdam and Eve. The story in Genesis 2-3 represents the beginning ofthe J narrative, the so-called Yahwist account of the creation which originated in the early years ofthe Israelite monarchy.8 Commentators have long acknowledged a variety ofelements in the Yahwist creation account which complicate its interpretation and defy any satisfactory explanation. Among the more puzzling elements in the story are, first, the implication in Gen. 3:22 of a plurality of divine beings, a fact which seems to contradict the rest ofthe narrative and which also flies in the face of Israelite monotheism. Second, according to Gen. 2:17, God threatens Adam with the punishment of 8 The Yahwist document, originally independent, was later combined with three other strands of ancient material to form the Pentateuch. For a recent study ofthe "Documentary Hypothesis," see Richard Friedman. 1 84Paul DuffandJoseph Hallman immediate death for transgressing the deity's prohibition (cf. 3:3, 3:4). God does not carry out the threatened punishment, however, nor does the text offer the reader an explanation for the deity's commutation ofthe sentence (Westermann 224-5). Third, the origin and nature ofthe serpent in the story is unclear. Where did he come from? The identification ofthis figure with Satan in the later tradition has no support in the text (Westermann 237-9). Finally, the prohibition not to eat ofthe single tree in the garden appears to be arbitrary. Hence the crime of Adam and Eve is obviously contrived. Despite the fact that the original sentence of death for their disobedience was not carried out, the curses invoked on Adam and Eve seem hardly warranted by the offense. Consequently, some sections ofthe text depict the deity as a petty tyrant, certainly a very different picture than that given by other scriptures ofthe Jewish and Christian traditions. We believe these difficulties can be overcome by approaching Genesis 2-3 from a Girardian perspective.9 We propose that this story has evolved10 in order to hide its original meaning. As a result—following Girard's understanding of the function and evolution of mythology—we will endeavor to "deconstruct" Genesis 2-3 in order to trace the evolution ofthis myth from its origin in a primal crime. This will enable us to explain the inconsistencies in the text as it stands and to appreciate the final revisions made by the biblical author(s). We will begin with a brief discussion of Girard's understanding ofmyth. Then we will turn to the problems ofthe Genesis text. Girard on myth According to Girard, myth is, quite simply, a narrative about a primal murder, rewritten from the vantage point ofthe killers (1977a, 64-7, 91-5; 1986, 24-44). As such, mythology covers up the role of the victimage mechanism as the basis ofculture. Myths which disguise or cover up such a crime can take many forms. For instance, the foundational murder of an 9 In his recent book on Paul, Robert Hamerton-Kelly presents a Girardian interpretation of this passage which is completely different from ours (92-7). Since Hamerton-Kelly appears to read the myth at face value without a sense of development, he, like most interpreters, ends with somewhat tortuous conclusions. 10It is virtually certain that the account found in Gen. 2 and 3 did not come into being as a free composition of the Yahwist. But, as Claus Westermann has pointed out in his history ofthe exegesis ofthis passage (186-91), despite the fact that most see it as a product of a long... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.2 (2002) 131-136 [Access article in PDF] Language, Logic, and Recovery:A Commentary on van Staden Paul Falzer and Larry Davidson Keywords: analytic philosophy, experience, Frege, ordinary language, psychosis, psychotherapy. VAN STADEN'S PAPER, "Linguistic Markers of Recovery," takes on a formidable task. As he explains it, findings from a previously conducted empirical study suggest that recovery from a psychiatric condition can be predicted by certain (...) patterns of first person pronoun usage. His current paper explains how these patterns follow the mathematical logic of Gottlob Frege. van Staden's attempt to systematize the link between language and treatment outcome shows promise. We want to support his effort by raising a few caveats about the application of foundational systems in psychiatry and psychology, particularly the advisability of employing a logical system to explain recovery from mental illness. Along the way, we will be identifying related issues that the author may elect to take up in his future work.van Staden's proposal is inspired by Frege's logical system, but the paper is, at the very least, an innovative adaptation. There are various points where we are left to wonder just how much of this proposal is really Frege's. Nevertheless, the genesis of van Staden's ideas is so dependent that one would expect a fuller account of Frege's pivotal role in the development of modern logic, how his work precipitated what is known commonly as the linguistic turn, and why a logical system that was so well received when first articulated was eclipsed so quickly by Russell's Principia (1963) and Wittgenstein's Tractatus. (1981) These issues can be addressed separately and perhaps they should, because lacking an account of how Frege's philosophy developed and evolved makes the presentation appear somewhat sketchy and incomplete.Frege is portrayed in philosophical lore as the founder of modern logic and a pioneer of the movement that later became known as analytic philosophy. Dummett (1991) regards Frege's Foundations of Arithmetic (1968) as analytical philosophy's first work (p. 111). According to Quine (1955), "All modern logic owes an incalculable debt to Frege. If anyone can be singled out as the founder of mathematical logic, it is by all odds he" (p. 158). Rorty (1967) notes that analytic philosophy's tack of construing philosophical questions as turning on language use and construction challenges the entire tradition, from Parmenides forward. However, the challenge reaches fruition not in Frege, but in works of Moore, Wittgenstein, and Austin. Rather than [End Page 131] sharing the limelight with the great analytic philosophers, Frege has become somewhat of a peripheral figure, whose contribution is usually portrayed as transitional. In some respects, analytic philosophy was moving against Frege's, and later, Russell's logical systems as it was concomitantly countering the various strands of idealism expounded principally by Bradley and McTaggart (see Hacker 1996, 5-12). Almost from the outset, Fregean logic was caught in a cross fire, and the author is obligated to tell us why we should be attending to the pristine version and not the more fully developed approaches that came soon after.Such a justification undoubtedly would begin with the dictum most central to Frege's philosophical thought, that propositions are primary. For Kemp (1998), this declaration carries two interrelated implications: Logical propositions are the real bearers of truth and falsity, and reasoning is a movement from one judgment to another (see p. 218). Frege posits that propositions are independent of mind, grammar, and language use. Knowledge and cognition are embodied in, but do not predicate, judgment. Frege adamantly rejects the notion that philosophical concepts are grounded in psychological phenomena, such as perception, sense impression, and some traditional accounts of meaning. This is the doctrine known as psychologism, and Frege abjures the suggestion that psychology can contain the sciences or adjudicate their findings (Frege 1956; for a discussion of this doctrine, see Notturno 1989; Davidson 1988; Davidson and Cosgrove 1991). The dictum that propositions are primary dispels the commonly held idea that reasoning begins with perception and proceeds... (shrink)

Available from UMI in association with The British Library. ;Is reason the slave of the passions? In Part I it is argued that neither the humean nor the kantian answers to this question can be maintained simpliciter. Each side of the controversy has to make significant concessions to the other. One consequence of this is that humean and kantian approaches to action are less clearly distinguished than might initially be supposed. ;In Part II several central notions are examined. The idea (...) of a pre-rational motive is rejected, as is the view that desires can be divided into motivated and unmotivated. The assumption that reason in action always takes the form of deductive argument is also rejected. An alternative view is presented that reason in action is to be understood in terms of the process of questioning a person's motives. There is no specific point which must always mark the termination of such a process. The circumstances in which questioning takes place are at least as important as the form answers to questions take. ;This implies that both the humean and kantian accounts of morality are unacceptable as complete moral theories. Moral deadlock does not result solely from conflicts of wants or of understanding. Equally it is not explicable in terms of different cultures. Different ways we talk of virtue reveal both humean and kantian strands in our moral thinking. Also the idea of moral progress reveals a kantian related notion of the form of a person's motives as a guide to changing for the better. (shrink)

Norman Daniels’s theory of health justice is the most comprehensive and systematic such theory we have. In one of the few articles published so far on Daniels’s new book, Just Health, Benjamin Sachs argues that Daniels’s core “principle of equality of opportunity does not do the work Daniels needs it to do.” Yet Sachs’s objections to Daniels’s framework are deeply flawed. Where these arguments do not rely on significant misreadings of Daniels, they ignore sensible strands in Just Health that considerably (...) dull their force. After disarming Sachs’s arguments against Daniels’s theory, I explain why I agree with Sachs’s conclusion: Daniels’s equality of opportunity-based account of health justice rests on shaky foundations. (shrink)

Philosopher William Lane Craig of the Talbot School of Theology has published three other Kluwer books on time and eternity and God’s relationship to them. In this book, Craig draws some important strands together regarding the concept of God and relativity theory. He notes the striking “paucity of integrative literature” in this regard: “I am convinced that this lack is largely due to the fact that theologians and philosophers of religion do not understand Einstein’s theories and so are reduced to (...) merely parroting what they read in scientific popularizations,” resulting in “a superficial and uncritical interaction”. (shrink)

This book is the fourth in a series of essay collections on defences in private law. It addresses defences to liability arising in equity. The essays range from those adopting a mainly doctrinal perspective to others that explore the law from a more philosophical perspective. Some essays concentrate on specific defences, while others are concerned with the links between defences, or with how defences relate to the structure of the law of equity generally. One aim of the book is to (...) shed light on equitable doctrines by analysing them through the lens of defences. The essays offer original contributions to this complex, important but neglected field of scholarly investigation. The contributors – judges, practitioners and academics – are all distinguished jurists. The essays are addressed to all of the major common law jurisdictions. (shrink)

The Existentialist Reader is a comprehensive anthology of classic philosophical writings from eight key existentialist thinkers: Sartre, Camus, Heidegger, de Beauvoir, Jaspers, Marcel, Merleau-Ponty, and Ortega y Gasset. These substantial and carefully selected readings consider the distinctive concerns of existentialism: absurdity, anxiety, alienation, death. A comprehensive introduction by Paul S. MacDonald illuminates the existentialist quest for individual freedom and authentic human experience with insight into the historical and intellectual background of these major figures. The Existentialist Reader is a valuable (...) guide to the provocative theories that shook the philosophical world in the 1930s and continue to profoundly shape the way we think about ourselves. (shrink)

Voluntariness of consent to research has not been sufficiently explored through empirical research. The aims of this study were to develop a more comprehensive approach to assessing voluntariness and to generate preliminary data on the extent and correlates of limitations on voluntariness. We developed a questionnaire to evaluate subjects’ reported motivations and constraints on voluntariness. 88 subjects in five different areas of clinical research—substance abuse, cancer, HIV, interventional cardiology, and depression—were assessed. Subjects reported a variety of motivations for participation. Offers (...) of financial incentives were common but not influential, pressures from others were rare, and no threats were reported. However, certain financial incentives and—paradoxically—altruistic motivations led some subjects to feel more constrained. Consistent with previous studies, no one pattern of motivation was common to all research subjects. There was little evidence of constrained voluntariness, but some suggestion of areas of concern. Voluntariness appears to be susceptible to systematic empirical investigation. (shrink)

Volume 19, Issue 5, May 2019, Page 22-24.

In lieu of an abstract, here is a brief excerpt of the content:Ought We to Require Emotional Capacity as Part of Decisional Competence?Paul S. Appelbaum* (bio)AbstractThe preceding commentary by Louis Charland suggests that traditional cognitive views of decision-making competence err in not taking into account patients’ emotional capacities. Examined closely, however, Charland’s argument fails to escape the cognitive bias that he condemns. However, there may be stronger arguments for broadening the focus of competence assessment to include emotional capacities, centering (...) on the ways in which emotions aid humans in processing information. Before emotional capacities are added to the list of functions essential for decisional competence, though, the feasibility and utility of such a reorientation must be demonstrated.To what extent ought persons’ capacities to experience emotion be taken into account when determining whether they should be deemed competent to make their own decisions? In the previous article, Louis Charland (1998) argues that traditional models of decision-making competence—of which the MacArthur Competence Treatment Study is a typical example—are mistaken in focusing narrowly on persons’ cognitive abilities to the neglect of emotional factors. In contrast, he suggests, constructs of competence ought explicitly to require a capacity to experience emotions, which he believes is central to meaningful decision making, before deeming persons competent.Charland, as he acknowledges, is not the first to suggest that the presence of some degree of emotional capacity is a necessary element of competence, but his argument is among the most elaborate to date and is certainly worth closer examination. Looked at carefully, however, Charland’s argument does not make quite the case for the determination of emotional capacity in competence assessment that he claims for it. Indeed, as I demonstrate below, Charland may share the same “pernicious [End Page 377] cognitive bias” that he ascribes to more traditional approaches. However, despite what I identify as the problems in Charland’s argument, others have raised more disturbing questions about the lack of attention to emotional issues in competence assessment. Thus, I am not ready to reject entirely the possibility that determinations of decisional competence ought to consider emotional factors. I conclude by outlining the questions that remain to be answered to identify more clearly the potential benefits of such an approach.The Construct of Decision-Making CompetenceSome preliminary comments about the nature of the dominant construct of decision-making competence may provide a useful frame for my response to Charland’s paper. Contemporary ideas of competence are tied inextricably to the ideal of self-determination in modern Western societies. Such societies are committed to respect for individual choice, both as a good in its own right and on the grounds that each person knows best what choices will maximize his or her own welfare. In general, therefore, states will not intervene to prevent persons from acting on their decisions, even when the choices they make—like the decision to smoke or to refuse potentially life-saving medical care—may objectively be thought to be detrimental to them.In some cases, however, the presumption that people will act in their own interests, as well as the notion that there is something intrinsically valuable in respecting their choices, fails (Buchanan and Brock 1989). When people’s minds are so disordered that they cannot be said to be making meaningful choices, other values come into play. Such people are called “incompetent.” When persons reach that point, the state’s interest in protecting its citizens becomes primary and someone else must make decisions on their behalf. Note that the size of this group must be sharply limited, lest a liberal society’s commitment to self-determination be undermined: There is no more profound infringement of the rights of citizens than the determination that they are incompetent. Thus, the criteria for incompetence must be selected in a deliberately narrow fashion—alternately, one might say that the standards for competence are made intentionally broad—so that all but a tiny percentage of citizens will be permitted to make decisions on their own.In the Anglo-American world, the process of formulating criteria of competence by and large has been left to the common law courts. Over the course of centuries they have identified the capacities that are, in... (shrink)

(2002). Clarifying the Ethics of Clinical Research: A Path toward Avoiding the Therapeutic Misconception. The American Journal of Bioethics: Vol. 2, No. 2, pp. 22-23.

Genomic research—including whole genome sequencing and whole exome sequencing—has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research—historically referred to as “incidental findings”—has generated considerable discussion as to how this information should be handled—that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of “the procedures to be followed” in (...) the research as part of the informed consent process. It seems reasonable to assume—and indeed, many commentators have concluded—that genomic investigators will be expected to inform participants about, among other procedures, the prospect that incidental findings will become available and the mechanisms for dealing with them. Investigators, most of whom will not have dealt with these issues before, will face considerable challenges in framing meaningful disclosures for research participants.To help in this task, we undertook to identify the elements that should be included in the informed consent process related to incidental findings. We did this by surveying a large number of genomic researchers (n = 241) and by conducting in‐depth interviews with a smaller number of researchers (n = 28) and genomic research participants (n = 20). Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect of incidental findings exists. Ensuring that participants’ decisions are informed and meaningful will require innovative approaches to dealing with the consent issue. We have identified four prototypical models of a consent process for return of incidental findings. (shrink)

: Responding to the paper by Miller and Joffe, we review the development of the concept of therapeutic misconception (TM). Our concerns about TM's impact on informed consent do not derive from the belief that research subjects have poorer outcomes than persons receiving ordinary clinical care. Rather, we believe that subjects with TM cannot give an adequate informed consent to research participation, which harms their dignitary interests and their abilities to make meaningful decisions. Ironically, Miller and Joffe's approach ends up (...) largely embracing the very position that they inaccurately attribute to us: the belief that, with some exceptions, it is only the prospect of poorer outcomes that should motivate efforts to dispel TM. In the absence of empirical studies on the steps required to dispel TM and the impact of such procedures on subject recruitment, it is premature to surrender to the belief that TM must be widely tolerated in clinical research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Examining the Ethics of Human Subjects ResearchPaul S. Appelbaum (bio)The work of the Advisory Committee on Human Radiation Experiments confirms once again the value of combining empirical and normative approaches to problems in clinical and research ethics. The Committee, like its predecessor, the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, spent relatively modest sums of money gathering targeted data to inform (...) its deliberations. The results of the Committee’s research, which are discussed by Nancy Kass and Jeremy Sugarman in this issue of the Kennedy Institute of Ethics Journal, enhance our understanding of the current ethical status of human subjects research, helping to focus attention on areas of particular concern, and lay the basis for future research and policy development.My comments here focus on the two major empirical studies conducted by the Committee—the Research Proposal Review Project and the Subject Interview Study. I will underscore just a few of the primary findings from these studies, consider their limitations, and explore their implications. Readers interested in the details of the studies should consult the Committee’s Final Report (ACHRE 1995), on which I rely in part and which provides additional information on the methodology and findings of the studies.Research Proposal Review ProjectWhat can be learned from the Committee’s review of 125 federally-funded human research studies? In answering that question, one cannot ignore the irony inherent in the Committee’s decision to review documents related to institutional review board (IRB) consideration of the selected protocols. The single most frequent complaint about the current system for protecting human subjects is that IRBs focus almost exclusively on review of consent forms and other research documents, as if they bore some close relationship to what actually transpires between investigators and potential research subjects. Only a small number of studies examine the research consent process. Nevertheless, existing data strongly [End Page 283] suggest that subject recruitment often involves an extended process of courtship, during which the information contained in consent forms is only a small part of the information passed between investigators and subjects (Benson, Roth, and Winslade 1985; Lidz et al. 1984).Indeed, the second of the Committee’s studies—the Subject Interview Study, which is discussed below—appears to confirm these findings. In-depth interviews with 99 individuals who reported that they were former or current research subjects suggest that “[f]or many, the decision to participate seemed to have been made before the consent form was given to them, and they signed it almost as a formality” (ACHRE 1995 [GPO, p. 742; Oxford, p. 471]). 1 Why, then, did the Committee focus its attention on documents that in many cases seem to play only a tangential role in the consent process? As is the case with IRBs around the country, the answer appears to be that consent forms and related documents are the only easily available window on consent transactions. In addition, under the current system, consent forms constitute the part of the process that IRBs can influence most easily. Consequently, it suits almost everyone’s needs—except perhaps those of the research subjects—to pretend that they reflect what actually transpires in the recruitment process. To the Committee’s credit, it was well aware of this dilemma. Nonetheless, it struggled to wring valid lessons from these limited data in its Final Report.Perhaps the most interesting finding from the Research Proposal Review Project is just how poor so many consent forms are. Given the disproportionate emphasis that many IRBs place on the content of the forms, one would expect that investigators by now would have learned to design documents that meet objective standards of adequacy, such as those applied by the Committee. Indeed, except in the most unusual circumstances, doing so would virtually guarantee that the IRB will ask no further questions about subject recruitment procedures. Although the data justify the inference that many investigators do not yet understand which information is essential to communicate to potential subjects, nor have learned how to do so effectively, they also force us to a still more radical conclusion. If the IRBs were doing their jobs, the Committee... (shrink)

This book is an inquiry into the motivation for altruistic behavior. It uncovers the condition that prompts or sometimes even compels us to act intentionally for the benefit of others. This condition, the pre-reflective experience of another person as a self-conscious individual just like oneself, finds its origin in the very structure of the mind. The essay is a synthesis of evidence from neuroscience, phenomenology, Eastern philosophy, analytic philosophy of mind, and cognitive psychology. Hence, it is an excellent example of (...) work in applied cognitive science. The book includes a critique of the several main approaches to the explanation of the motivation for altruistic behavior: biological, psychological, and philosophical. The path of the main inquiry produces several innovative proposals in the philosophy of mind in addition to the main conclusion. Included in these are a detailed account of the structure of the human mind, an ontological categorization of mental states, a naturalistic explanation of so-called mystical states, a proposal for the role of consciousness in the downward causation of physical events, a new interpretation of the Buddhist doctrine of no-self and a unique view of the nature of love. (shrink)

Thomas Jefferson and Philosophy: Essays on the Philosophical Cast of Jefferson’s Writings is a collection of essays on topics that relate to philosophical aspects of Jefferson’s thinking over the years. Much historical insight is given to ground the various philosophical strands in Jefferson’s thought and writing on topics such as political philosophy, moral philosophy, slavery, republicanism, wall of separation, liberty, educational philosophy, and architecture.

Liberal societies are built on a foundation of personal rights, including the right to make decisions about the medical treatment that one will receive or decline to receive. So essential to the liberal project is the power of individual choice that it will be abrogated only in the most extreme situations, in which persons seem to be unable to make rational decisions and thereby to protect their interests. A small number of decision-related abilities have been identified as relevant to the (...) determination of when a person will be deemed decisionally incapable: understanding, appreciation, reasoning, and choice. It would seem prudent to tinker with these standards cautiously—if at all.... (shrink)

Some years ago I received a phone call telling me that my mother, then in her eighties, had been found wandering the street outside her home. It was the first indication my wife and I had of Alzheimer's disease. We arrived to discover that my mother was incoherent, with the house in disorder, bills unpaid, and perishable food in the night table rather than the refrigerator. Having spent much of my career trying to improve the assessment of decisional capacity, in (...) part to avoid unnecessary deprivation of decision-making rights, I did not take lightly the step to have my mother declared incompetent. But it was necessary. This episode has been on my mind since I returned recently from a conference in Paris devoted to the United Nations Convention on the Rights of Persons with Disabilities. (shrink)

The American Journal of Bioethics, Volume 11, Issue 8, Page 17-18, August 2011.